When Walt Disney was looking for the location of his new Theme Park complex, Disneyworld, he selected Orlando because it was centrally located along I-4 (between Daytona and Tampa) and along the Florida Turnpike. Orlando is easily accessed from the Northeast via I-95 to I-4 in Daytona. If you're in the Midwest, I-75 connects with The Florida Turnpike in Wildwood. Cincinnati is about a 14 hour drive and Washington DC is about a 12 hour drive.
If you drive to Florida, be sure to stop at a Florida welcome center when you enter the state for a complimentary glass of sunshine, Florida Orange Juice, the best Orange Juice in the world.